Leng Chee Chang | Pharmacology | Research Excellence Award

Prof. Dr. Leng Chee Chang | Pharmacology | Research Excellence Award

University of Hawaii at Hilo | United States

Prof. Dr. Leng Chee Chang is a natural products chemist whose work focuses on the isolation, characterization, and biological evaluation of bioactive compounds from medicinal plants, marine algae, and microbes with applications in cancer chemoprevention, chemotherapeutics, and antimicrobial discovery. According to Scopus-indexed records, she has authored 73 publications, which have been cited 2,567 times, reflecting a substantial global research impact. Her h-index of 28 highlights consistent scholarly influence and sustained citation performance across her body of work. Dr. Chang’s research has appeared in high-impact journals such as Organic Letters, Journal of Natural Products, Molecules, and ACS Omega, and encompasses multidisciplinary collaborations in pharmacognosy, medicinal chemistry, and pharmacology. Her work has contributed to the discovery of novel natural products with therapeutic potential.

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Featured Publications


A New Trichlorinated Xanthone and Compounds Isolated from Cladonia skottsbergii with Antimicrobial Properties

– Rositzki MJ, Raksat A, Simmons CJ, Smith C, Reverend Danette V. Choi, Wongwiwatthananukit S, Chang LC · Pharmaceuticals, 2026


Bioactive Constituents from the Edible Seaweed Halymenia hawaiiana (Rhodophyta)

– Raksat A, Atanu MSH, McDermimid KJ, Wall MW, Chang BL, Wongwiwatthananukit S, Chang LC · Pharmaceutical Biology, 2025


Bioactive Compounds from Dodonaea viscosa Flowers: Potent Antibacterial and Antiproliferative Effects in Breast Cancer Cells

– Raksat A, Yee D, Gi YJ, Wongwiwatthananukit S, Chang LK, Kaawaloa P, Wall MW, Chang LC · Molecules, 2025 (IF 4.2)


Biologically Active Withanolides from Physalis peruviana L.

– Sang-Ngern M, Fukuchi A, Kondratyuk TP, Park E-J, Simmons CJ, Wall MW, Lorch SE, Pezzuto JM, Chang LC · Pharmaceutical Biology, 2025


Vernonolide A, a Sesquiterpene Lactone with a Unique Carbon Skeleton from Vernonia cinerea

– Zhang M, Kondratyuk TP, Cao S, Li M, Songsak T, Wongwiwatthananukit S, Cai Y-S, Chang LC · Organic Letters, 2025 (IF 4.9)

 

Giuseppe Federighi | Medicine and Health Sciences | Research Excellence Award

Dr. Giuseppe Federighi | Medicine and Health Sciences | Research Excellence Award

University of Pisa | Italy

Dr. Giuseppe Federighi is a neuroscientist and molecular biologist whose research focuses on gene expression regulation, neurovascular physiology, oxidative stress, and experimental hypertension. His work integrates molecular neuroscience with functional and behavioral approaches in animal models to investigate mechanisms underlying neuroprotection, cerebrovascular regulation, and metabolic modulation. He has made notable contributions to studies on acetyl-L-carnitine, antioxidant interventions, mandibular extension–induced hypotension, and cerebral microcirculation. According to Scopus, he has authored 19 peer-reviewed publications, received 153 citations, and holds an h-index of 7. His research outputs are published in high-visibility journals such as Molecular Neurobiology, PLoS One, Scientific Reports, and Frontiers in Physiology.

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Featured Publications


Physical exercise improves total antioxidant capacity and gene expression in rat hippocampal tissue

– F. Franzoni, G. Federighi, J. Fusi, et al. · Archives italiennes de biologie, 2017 · Cited by 38


Modulation of Myelin Basic Protein Gene Expression by Acetyl-l-Carnitine

– G. Traina, G. Federighi, M. Macchi, et al. · Molecular Neurobiology, 2011 · Cited by 27


Cytoprotective Effect of Acetyl-l-Carnitine Evidenced by Analysis of Gene Expression in the Rat Brain

– G. Traina, G. Federighi, M. Brunelli, R. Scuri · Molecular Neurobiology, 2009 · Cited by 25


Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer’s disease

– G. Traina, G. Federighi, M. Brunelli · Neurochemistry International, 2008 · Cited by 24


Modulation of gene expression in contextual fear conditioning in the rat

– G. Federighi, G. Traina, M. Macchi, et al. · PLoS One, 2013 · Cited by 17