Huai-Jen Tsai | Biochemistry, Genetics and Molecular Biology | Research Excellence Award

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Prof. Dr. Huai-Jen Tsai | Biochemistry, Genetics and Molecular Biology | Research Excellence Award

Institute of Life Science, Fu-Jen Catholic University | Taiwan

Prof. Dr. Huai-Jen Tsai is a distinguished molecular biologist whose research spans developmental biology, marine biotechnology, and gene transgenesis in aquatic organisms, with a particular focus on zebrafish and other finfish models. He has pioneered innovative sperm-mediated and electroporation-based gene transfer systems, enabling highly efficient transgenesis in finfish and shellfish, and has significantly advanced understanding of growth hormone regulation, gonadotropins, rhodopsins, and muscle-specific transcription factors, thereby contributing to both vertebrate developmental biology and aquaculture applications. Prof. Dr. Huai-Jen Tsai’s work bridges fundamental molecular biology and applied biotechnology, investigating molecular mechanisms regulating embryonic development, stress responses, and neural regeneration, including studies on ENDOU-mediated translation regulation and the role of extracellular proteins in promoting neurite outgrowth and spinal cord repair. He has authored 162 documents indexed in Scopus, which have been cited over 5,174 times by 4,191 publications, and he holds an h-index of 36, reflecting the high impact and wide recognition of his contributions in the scientific community. Throughout his career, Prof. Dr. Huai-Jen Tsai has received numerous prestigious awards, including the MOST Outstanding Research Award, Y. Z. Hsu Technology Invention Award for a patented zebrafish gene fragment, and multiple NSC Outstanding Research Awards, and he has served as principal investigator on numerous funded research projects. In addition, he contributes extensively as a reviewer and editorial board member for international journals. His research continues to integrate molecular genetics, developmental studies, and biotechnological innovation, establishing him as a leading authority in aquatic molecular genetics, transgenic technologies, and regenerative biology, and underscoring his influential role in advancing both basic science and translational applications in vertebrate and aquatic systems.

Profiles: Scopus | ORCID

Featured Publications

  • Lee, H.-C., Huang, Y.-H., Hsieh, C.-C., Ke, Y.-N., & Tsai, H.-J. (2025). ENDOU-1-induced cytoplasmic HnRNPA3 recognizes m6A methylation on the upstream reading frame of human CHOP transcripts to achieve maximal CHOP translation. Preprint.

  • Lee, B.-C., Tsai, J.-C., Huang, Y.-H., Wang, C.-C., Lee, H.-C., & Tsai, H.-J. (2024). The 419th aspartic acid of neural membrane protein enolase 2 is a key residue involved in axonal growth of motor neurons mediated by interaction between enolase 2 receptor and extracellular Pgk1 ligand. International Journal of Molecular Sciences, 25(19), 10753.

  • Lee, H.-C., Chao, H.-T., Lee, S. Y.-H., Lin, C.-Y., & Tsai, H.-J. (2023). The upstream 1350~1250 nucleotide sequences of the human ENDOU-1 gene contain critical cis-elements responsible for upregulating its transcription during ER stress. International Journal of Molecular Sciences, 24(24), 17393.

  • Zeng, C.-W., & Tsai, H.-J. (2023). The promising role of a zebrafish model employed in neural regeneration following a spinal cord injury. International Journal of Molecular Sciences, 24(18), 13938.

  • Fu, C.-Y., Chen, H.-Y., Lin, C.-Y., Chen, S.-J., Sheu, J.-C., & Tsai, H.-J. (2023). Extracellular Pgk1 interacts with neural membrane protein enolase-2 to improve neurite outgrowth of motor neurons. Communications Biology, 6, 822.

Meng Ning | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

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Dr. Meng Ning | Biochemistry, Genetics and Molecular Biology | Best Researcher Award

Chiba University | China

Dr. Meng Ning is an accomplished researcher at Chiba University, Japan, recognized for her pioneering work in the epigenetic regulation of cancer. She has made substantial contributions to understanding the non-catalytic roles of chromatin regulators, particularly in gastric cancer. Her expertise bridges molecular biology and clinical gastrointestinal oncology, enabling her to translate laboratory discoveries into potential therapeutic strategies. Meng Ning is known for her meticulous experimental design, innovative application of genome-editing technologies, and dedication to advancing cancer research through both independent studies and collaborative projects.

Professional Profile

ORCID

Education

Dr. Meng Ning completed her doctoral studies at Chiba University, Japan, where she focused on elucidating novel mechanisms of cancer progression. Her Ph.D. research revealed a previously unrecognized non-catalytic function of SETD1A in gastric cancer via the E2F4–TAF6 axis. Employing advanced techniques including transcriptomics, epigenomics, and genome-editing approaches, she was able to demonstrate this mechanism independently of traditional methyltransferase activity. Her academic training combines rigorous laboratory research with a strong foundation in clinical oncology, preparing her to conduct translational studies that link fundamental discoveries with therapeutic potential.

Experience

Dr. Meng Ning has extensive experience in both experimental and translational cancer research. She has collaborated with the Department of Pathology at the University of Tokyo to analyze clinical gastric cancer specimens, integrating molecular findings with patient data. Her work spans NGS-based studies, CRISPR genome editing, and multi-omics analyses, reflecting a versatile approach to cancer biology. Beyond laboratory research, she has contributed to the mentorship of junior researchers, participated in collaborative projects across institutions, and actively engaged in the scientific community through professional society memberships and research networks.

Research Interests

Dr. Meng Ning’s primary research interest lies in the epigenetic regulation of cancer, with a focus on non-catalytic functions of chromatin regulators. She investigates how these regulators influence tumor proliferation, cellular signaling, and transcriptional networks using advanced molecular biology techniques. Her research integrates next-generation sequencing, genome editing, and integrative bioinformatics to identify novel mechanisms underlying cancer progression. By connecting these molecular insights with clinical oncology, she aims to identify potential therapeutic targets and contribute to the development of innovative cancer treatments.

Awards

Dr. Meng Ning is nominated for the Best Researcher Award in recognition of her outstanding contributions to cancer epigenetics and translational oncology. Her research has introduced novel concepts in understanding chromatin regulator function and tumor biology, demonstrating originality, technical excellence, and significant impact in the field. Her dedication to advancing cancer research through rigorous experimentation and collaborative endeavors positions her as a leading researcher in her discipline.

Publications

Dr. Meng Ning has authored several high-impact, SCI-indexed publications as first or contributing author. Her work demonstrates innovative methodologies and deep insights into the molecular mechanisms of cancer:

Title: Non-catalytic role of SETD1A promotes gastric cancer cell proliferation through the E2F4–TAF6 axis in the cell cycle
Journal: Cell Death & Disease
Published on: 2025-08-23

Title: Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K
Journal: Breast Cancer Research
Published on: 2025-08-11

Title: Integrated enhancer regulatory network by enhancer–promoter looping in gastric cancer
Journal: NAR Cancer
Published on: 2024-04-08

Conclusion

Dr. Meng Ning exemplifies excellence in scientific research through her innovative studies in cancer epigenetics and her commitment to translational application. Her work bridges basic molecular discoveries and clinical oncology, offering new avenues for therapeutic development. With a combination of technical skill, collaborative engagement, and visionary research, Meng Ning stands out as a highly deserving candidate for the Best Researcher Award. Her contributions not only advance the understanding of cancer biology but also inspire ongoing innovation in epigenetic and translational research.

Kuang-Wei Wang | Molecular Biology | Best Researcher Award

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Mr. Kuang-Wei Wang | Molecular Biology | Best Researcher Award

Michigan State University | United States

Kuang-Wei Wang is a dedicated Ph.D. candidate in Biochemistry and Molecular Biology at Michigan State University, with a keen focus on tauopathies such as Alzheimer’s disease. His research expertise spans protein characterization, molecular imaging, and cell culture, contributing significantly to the understanding of hyperphosphorylated tau protein mechanisms and drug discovery. Kuang-Wei’s passion lies in translating scientific findings into therapeutic advancements, showcasing his aptitude for independent research and interdisciplinary collaboration.

Professional profile👤

Scopus

Strengths for the Awards✨

  • 🌟 Specialized Research Focus: Kuang-Wei Wang’s research into tauopathies, particularly Alzheimer’s disease, is highly relevant and impactful, addressing one of the most pressing neurodegenerative diseases.

  • 📊 Diverse Skill Set: Proficiency in advanced techniques such as protein engineering, high-throughput screening, transmission electron microscopy, and flow cytometry highlights a strong technical foundation.

  • 📚 Publication Record: Several peer-reviewed publications in reputable journals, including Molecular Neurobiology and ACS Chemical Neuroscience, demonstrate a track record of contributing new knowledge to the field.

  • 🔬 Research Experience: Independent and collaborative research in both cellular models and in vivo mouse models indicates well-rounded expertise. Contributions to a 100K-compound high-throughput screening for drug discovery further showcase his ability to handle large-scale projects.

  • 🌐 Presentation and Communication: Presenting at international conferences reflects his engagement with the broader scientific community and ability to communicate findings effectively.

🎓 Education

Kuang-Wei Wang pursued his Ph.D. in Biochemistry and Molecular Biology at Michigan State University (2019 – Present), where he centered his research on Alzheimer’s disease mechanisms and drug discovery. Prior to this, he earned dual B.S. degrees in Applied Chemistry and Interdisciplinary Science Degree Program from National Chiao Tung University, Taiwan (2011 – 2015), solidifying his foundation in chemical and biological sciences.

💼 Experience

Currently, Kuang-Wei is conducting his doctoral research in the Kuo Lab at Michigan State University, under the guidance of Dr. Min-Hao Kuo. His work involves using advanced techniques such as Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and transmission electron microscopy (TEM) to characterize the biophysical properties of hyperphosphorylated tau protein. He has explored the effects of cytotoxic p-tau across various models, including human cell lines, mouse primary neurons, and in vivo mouse models, contributing to high-throughput screening (HTS) that identified novel inhibitors for p-tau aggregation and cytotoxicity. Previously, he gained valuable experience as a research assistant in Dr. Yaw-Kuen Li’s lab at National Chiao Tung University, purifying macrolide glycosyltransferases and analyzing enzymatic reactions. His industry experience includes roles at DuPont Taiwan and Avision Inc., complemented by military service in Taiwan.

🔬 Research Interests On Molecular Biology

Kuang-Wei’s research interests revolve around unraveling the molecular mechanisms of neurodegenerative diseases, particularly tauopathies like Alzheimer’s disease. He is passionate about protein engineering, drug discovery, and developing high-throughput screening methods to identify small-molecule inhibitors that mitigate tau aggregation and cytotoxicity.

🏆 Awards

Kuang-Wei has demonstrated leadership through roles such as Captain of the Applied Chemistry Tennis Team, President of the Applied Chemistry Student Association, and General Coordinator for the Applied Chemistry Summer Camp. These experiences underscore his ability to lead and collaborate effectively in diverse environments.

📖 Publications

  • Title: Alzheimer’s Disease Drug Discovery: Small Molecule Inhibitors of Hyperphosphorylated Tau Aggregation and Cytotoxicity
    Authors: Wang, K. W., Hagar, H. C., Fernandez-Vega, V., Jordán, L. O., Scampavia, L., Shumate, J., Spicer, T., & Kuo, M. H.

  • Title: Effects of Heparan Sulfate Trisaccharide Containing Oleanolic Acid in Attenuating Hyperphosphorylated Tau-Induced Cell Dysfunction Associated with Alzheimer’s Disease
    Authors: Zhu, S., Song, Z., Tapayan, A., Singh, K., Wang, K. W., Hagar, H. C., Zhang, J., Kim, H., Thepsuwan, P., Kuo, M. H., Zhang, K., & Nguyen, H.
    Year: 2025
    Journal: Journal of Medicinal Chemistr

  • Title: Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine
    Authors: Wang, K. W., Hagar, H. C., Song, Z., Chen, H. R., Kuan, C. Y., Zhang, K., & Kuo, M. H.
    Year: 2024
    Journal: Molecular Neurobiology
    Citations: 61(5), p. 2653-2671

  • Title: Frontotemporal Dementia P301L Mutation Potentiates but Is Not Sufficient to Cause the Formation of Cytotoxic Fibrils of Tau
    Authors: Wang, K. W., Zhang, G., & Kuo, M. H.
    Year: 2023
    Journal: International Journal of Molecular Sciences
    Citations: 24(19), 14996

  • Title: Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation
    Authors: Ramirez, E., Ganegamage, S. K., Min, S., Patel, H., Ogunware, A., Plascencia-Villa, G., Alnakhala, H., Shimanaka, K., Tripathi, A., Wang, K. W., Zhu, X., Rochet, J. C., Kuo, M. H., Counts, S. E., Perry, G., Dettmer, U., Lasagna-Reeves, C. A., & Fortin, J. S.
    Year: 2023
    Journal: ACS Chemical Neuroscience
    Citations: 14(21), 3913–3927

  • Title: Anti-fibrillization Effects of Sulfonamide Derivatives on α-Synuclein and Hyperphosphorylated Tau Isoform 1N4R
    Authors: Fortin, J. S., Shimanaka, K., Saraswati, A. P., Liu, M., Wang, K. W., Hagar, H. T., Maity, S., Ganegamage, S. K., Ellsworth, E., Counts, S. E., Borhan, B., Dettmer, U., & Kuo, M. H.
    Year: 2022
    Journal: Journal of Molecular Structure
    Citations: 1267, 133574

  • Title: Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death
    Authors: Liu, M., Sui, D., Dexheimer, T., Hovde, S., Deng, X., Wang, K. W., Lin, H. L., Chien, H. T., Kweon, H. K., Kuo, N. S., Ayoub, C. A., Jimenez-Harrison, D., Andrews, P. C., Kwok, R., Bochar, D. A., Kuret, J., Fortin, J., Tsay, Y. G., & Kuo, M. H.
    Year: 2020
    Journal: Molecular Neurobiology
    Citations: 57(11), 4704–4719

🔝 Conclusion

Kuang-Wei Wang stands out as a passionate researcher driven to uncover the complexities of tauopathies and contribute to therapeutic advancements. His diverse experience in academia and industry, combined with his leadership roles and technical skills, make him a promising scientist in the field of neurodegenerative diseases. He continues to push the boundaries of knowledge, aiming to translate molecular insights into innovative treatments.