Qianghua Lv | Medicine | Best Researcher Award

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Prof. Dr. Qianghua Lv | Medicine | Best Researcher Award

Shandong Academy of Agricultural Sciences | China

Dr. Qianghua LV is an Associate Researcher at the Institute of Animal Science and Veterinary Medicine (IASVM), Shandong Academy of Agricultural Sciences (SAAS). He earned his Ph.D. in Veterinary Pharmacology under the mentorship of Prof. DENG Xuming at Jilin University in 2020. His research focuses on developing novel therapeutic strategies targeting bacterial virulence factors, including bacterial hemolysin, Type III Secretion System (T3SS), and Type IV Pili (TFP). His work contributes significantly to understanding anti-infective mechanisms and advancing new drug development against bacterial infections.

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ORCID

Strengths for the Awards✨

  • High-Impact Research Focus – Dr. LV Qianghua’s work on anti-infection mechanisms and natural compound-based drug development aligns with global health priorities, particularly in combating superbacterial infections. His research on bacterial virulence factors like hemolysin, T3SS, and TFP contributes to the development of novel antimicrobial strategies.

  • Quality Publications in Reputable Journals – He has multiple first-author and co-first-author publications in high-impact journals, such as Journal of Cellular and Molecular Medicine and Applied Microbiology and Biotechnology. These papers focus on novel antibacterial mechanisms and natural product inhibitors, demonstrating both innovation and scientific rigor.

  • Translational Impact – His research not only advances basic microbiology but also holds significant translational potential in developing new antibacterial therapies, an area of urgent medical need due to rising antibiotic resistance.

  • Collaborative and Multi-Disciplinary Approach – His collaborations with researchers across multiple disciplines (pharmacology, microbiology, and veterinary medicine) enhance the applicability of his findings beyond veterinary science, benefiting both animal and human health.

  • Contribution to Veterinary Medicine – As an Associate Researcher at the IASVM, SAAS, Dr. LV contributes significantly to veterinary pharmacology, a field essential for both agricultural and public health. His work has implications for livestock disease management and food safety, making it highly relevant for both academia and industry.

🎓 Education

  • Ph.D. in Veterinary Pharmacology, Jilin University, 2020
    • Advisor: Prof. DENG Xuming
    • Research Focus: Anti-infection mechanisms of natural compounds targeting bacterial virulence factors

đź’Ľ Experience

  • Associate Researcher, IASVM, SAAS (2020–Present)
    • Conducting research on antibacterial strategies targeting virulence factors
    • Screening natural compounds for inhibitory effects on bacterial infections
    • Developing new therapeutic agents against superbacterial infections

🔬 Research Interests On Medicine

  • 🦠 Discovery and screening of novel targets and lead compounds against superb acterial infections
  • đź’Š Synergistic antibacterial effects and mechanisms of natural compounds and antimicrobial agents

đź“š Selected Publications

  • Title: Inhibition of the type III secretion system by syringaldehyde protects mice from Salmonella enterica serovar Typhimurium
    Authors: Lv Q(#), Chu X(#), Yao X, Ma K, Zhang Y*, Deng X*
    Publication Year: 2019
    Journal: Journal of Cellular and Molecular Medicine

  • Title: Identification of the natural product paeonol derived from peony bark as an inhibitor of the Salmonella enterica serovar Typhimurium type III secretion system
    Authors: Lv Q(#), Li S(#), Wei H, Wen Z, Wang Y, Tang T, Wang J, Xia L*, Deng X*
    Publication Year: 2020
    Journal: Applied Microbiology and Biotechnology

  • Title: Phloretin potentiates polymyxin E activity against Gram-negative bacteria
    Authors: Du R(#), Lv Q(#), Hu W, Hou X, Zhou Y, Deng X, Sun L, Li L, Deng Y, Wang J
    Publication Year: 2021
    Journal: Life Sciences

  • Title: Commercialized artemisinin derivatives combined with colistin protect against critical Gram-negative bacterial infection
    Authors: Zhou Y, Liu B, Chu X, Su J, Xu L, Li L, Deng X, Li D*, Lv Q*, Wang J*
    Publication Year: 2022
    Journal: Communications Biology

  • Title: Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro
    Authors: Liu M(#), Lv Q(#), Xu J, Liu B, Zhou Y, Zhang S, Shen X, Wang L
    Publication Year: 2023
    Journal: Biochemical Pharmacology

🔚 Conclusion

Dr. LV Qianghua has dedicated his research to developing innovative antibacterial strategies, focusing on targeting bacterial virulence factors. His contributions in natural compound screening and new drug development have advanced the fight against superbacterial infections. With numerous impactful publications and ongoing research, he continues to make significant strides in veterinary medicine and pharmacology.

Dan Zhao | Biology | Best Researcher Award

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Dr. Dan Zhao | Biology | Best Researcher Award

Postdoc Fellow | Harvard medical school | United States

Dan Zhao, Ph.D., is a distinguished researcher in biochemistry and molecular biology, currently a Postdoctoral Fellow at Harvard University. With a strong background in protein quality control, ER-associated degradation (ERAD), and autophagy, Dr. Zhao has made significant contributions to understanding cellular homeostasis mechanisms. His research integrates cutting-edge techniques in cell biology, biochemistry, and structural analysis.

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ORCID

Strengths for the Awards✨

âś… Outstanding Research Impact: Dan Zhao has made significant contributions to biochemistry and molecular biology, particularly in ER-associated degradation (ERAD) and autophagy. His research has been published in high-impact journals such as Nature Structural & Molecular Biology, Molecular Cell, and Autophagy.

âś… Strong Academic and Research Background: His journey from Peking University to Harvard University, along with his research at prestigious institutions such as the National Institute of Biological Sciences (NIBS) and Howard Hughes Medical Institute (HHMI), showcases his academic excellence.

âś… Breakthrough Discoveries: His identification of Epr1 as the first soluble ER-phagy receptor and his work in ERAD have advanced fundamental knowledge in cell biology, making him a leader in his field.

âś… Recognized Achievements: Multiple awards and honors, including “Outstanding Researcher” at NIBS and a poster award at an International Symposium on Autophagy, highlight his scientific contributions.

âś… Consistent Conference Presentations: Presenting at prestigious international conferences (e.g., Gordon Research Conference, ASCB | EMBO Meeting) underscores his active engagement in the research community.

🎓 Education

  • Ph.D. in Biochemistry and Molecular Biology (2011 – 2017)
    Peking University & National Institute of Biological Sciences, Beijing, China
  • B.A. in Biological Sciences (2007 – 2011)
    Sichuan University, Chengdu, China

🧪 Experience

  • Postdoctoral Fellow (2021 – Present)
    Howard Hughes Medical Institute, Harvard University

    • Investigated how the Mnl1/Htm1-Pdi1 complex recognizes misfolded proteins and initiates ERAD.
    • Identified Pdi1 as the key reductase in ERAD.
    • Developed a novel assay for detecting mannosidase activity.

  • Research Associate (2017 – 2021)
    National Institute of Biological Sciences, Beijing, China

    • Discovered Epr1, the first soluble ER-phagy receptor.
    • Explored the molecular mechanisms of Epr1 in ER-phagy.
    • Characterized a novel protein, SPBC1685.04, in macroautophagy.

  • Ph.D. Candidate (2012 – 2017)
    Peking University-Tsinghua University-National Institute of Biological Sciences Joint Program

    • Studied PX-BAR family proteins and their role in organelle autophagy.
    • Investigated XRCC4 homologs in fission yeast.

  • Early Research Roles (2010 – 2012)

    • Conducted metagenomic sequencing of Cordyceps Sinensis.
    • Performed single-cell transcriptome sequencing.
    • Researched amyloid precursor protein (APP) processing.

🔬 Research Interests On Biology

  • Protein quality control and degradation
  • ER-associated degradation (ERAD)
  • Autophagy and ER-phagy mechanisms
  • Structural and functional analysis of protein complexes

🏆 Awards & Honors

  • 2017 – Excellent Graduate, Peking University
  • 2015 – Outstanding Researcher, National Institute of Biological Sciences
  • 2015 – Poster Award, International Symposium on Autophagy
  • 2014 – Best Oral Talk, Chinese Fungi Symposium
  • 2013 – Merit Student, Peking University
  • 2011 – Excellent Graduate, Sichuan University

đź“„ Publications

  • Initiation of ERAD by the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase

    • Authors: Dan Zhao; Xudong Wu; Tom A. Rapoport
    • Year: 2024

  • Visual detection of binary, ternary, and quaternary protein interactions in fission yeast using a Pil1 co-tethering assay

    • Authors: Zhong-Qiu Yu; Xiao-Man Liu; Dan Zhao; Dan-Dan Xu; Li-Lin Du
    • Year: 2021

  • Visual detection of binary, ternary, and quaternary protein-protein interactions in fission yeast by Pil1 co-tethering assay

    • Authors: Zhong-Qiu Yu; Xiao-Man Liu; Dan Zhao; Dan-Dan Xu; Li-Lin Du
    • Year: 2021

  • Atg38-Atg8 interaction in fission yeast establishes a positive feedback loop to promote autophagy

    • Authors: Zhong-Qiu Yu; Ling-Ling Sun; Zhao-Di Jiang; Xiao-Man Liu; Dan Zhao; Hai-Tao Wang; Wan-Zhong He; Meng-Qiu Dong; Li-Lin Du
    • Year: 2020

  • Epr1, a UPR-upregulated soluble autophagy receptor for reticulophagy

    • Authors: Dan Zhao; Li-Lin Du
    • Year: 2020

  • A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance

    • Authors: Dan Zhao
    • Year: 2020

  • Atg20 and Atg24 family proteins promote organelle autophagy in fission yeast

    • Authors: Dan Zhao
    • Year: 2016

  • Genome-wide Screens for Sensitivity to Ionizing Radiation Identify the Fission Yeast Nonhomologous End Joining Factor Xrc4

    • Authors: Dan Zhao
    • Year: 2014

🔍 Conclusion

Dr. Dan Zhao’s research has significantly advanced the understanding of protein degradation and autophagy. His discoveries, including the role of ER-phagy receptors and ERAD pathways, contribute to fundamental biological processes with implications for diseases like neurodegeneration. As a leading scientist in the field, his work continues to shape our understanding of cellular homeostasis.