Yan Bai | Medicine and Health Sciences | Best Researcher Award

Published on by Forensic Scientist

Dr. Yan Bai | Medicine and Health Sciences | Best Researcher Award

Yunnan University | China

Dr. Yan Bai is a highly accomplished postdoctoral researcher at the State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan and the Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China. She earned her PhD in Cell Biology from Yunnan University, MSc in Pharmacology from the Chinese PLA Medical Academy, and BSc in Pharmacy from Dali University, establishing a strong interdisciplinary foundation spanning pharmacology, microbiology, and cellular biology. Prior to her current role, she conducted research at the Chinese PLA General Hospital, focusing on combination therapies against multidrug-resistant bacteria. Her research primarily investigates mitochondrial homeostasis, tumor biology, and the molecular mechanisms underlying mitochondrial genetic diseases, with particular attention to mitochondria-associated condensates (MATOs) as regulators of protein translation and mitochondrial integrity. Dr. Yan Bai has led and contributed to several major research projects, including grants from the National Natural Science Foundation of China, the National Basic Research Program, and Yunnan Province Science and Technology initiatives. Her work has resulted in high-impact publications in journals such as Nature Aging (2025), Sci China Life Sci (2025), EMBO J (2024), and Biophys Rep (2024). According to Scopus, she has authored 10 publications, cited 177 times across 169 documents, with an h-index of 6, demonstrating both productivity and influence in her field. Through her interdisciplinary collaborations, innovative experimental approaches, and groundbreaking findings on mitochondrial regulation and aging, Dr. Yan Bai has made significant contributions to biomedical science, advancing understanding of mitochondrial biology, disease mechanisms, and translational biomedical applications.

Profile: Scopus

Featured Publications

Bai, Y., Ma, T., Zhao, S., Li, S., Wang, X., Li, J., Sun, W., Yang, Y., Liu, F., Shan, Q., Qin, Z., Liu, N., Zhang, J., Tian, F., Duan, M., Chen, S., Lai, F., Chen, Q., Wu, X., & Yang, C. (2025). Mitochondria-associated condensates maintain mitochondrial homeostasis and promote lifespan. Nature Aging.

Hao, Q., Bai, Y., Guan, R., Dong, R., Bai, W., Hamdy, H., Wang, L., Meng, M., Sun, Y., Shen, J., & Sun, J. (2025). VPS35/Retromer-dependent MT1-MMP regulation confers melanoma metastasis. Science China Life Sciences, 68(7), 1996–2009.

Hao, Q., Dong, R., Bai, W., Chang, D., Yao, X., Zhang, Y., Xu, H., Li, H., Kui, X., Wang, F., Wang, Y., Wang, C., Lei, Y., Chen, Y., Shen, J., Sang, L., Bai, Y., & Sun, J. (2024). Screening for metastasis-related genes in mouse melanoma cells through sequential tail vein injection. Biophysical Reports, 10(1), 15–21.

Liu, F., Li, T., Gong, H., Tian, F., Bai, Y., Wang, H., Yang, C., Li, Y., Guo, F., Liu, S., & Chen, Q. (2024). Structural insights into the molecular effects of the anthelmintics monepantel and betaine on the Caenorhabditis elegans acetylcholine receptor ACR-23. EMBO Journal, 43(17), 3787–3806.

Wang, T., Zhou, X., Bai, Y., Zhang, L., Li, L., & Wu, C. (2018). Antiepileptic effect of uridine may be caused by regulating dopamine release and receptor expression in corpus striatum. Brain Research, 1688, 47–53.

Bai, Y., Liu, B., Wang, T., Cai, Y., Liang, B., Wang, R., Liu, Y., & Wang, J. (2015). In vitro activities of combinations of rifampin with other antimicrobials against multidrug-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 59(3), 1466–1471.

Liu, B., Bai, Y., Liu, Y., Di, X., Zhang, X., Wang, R., & Wang, J. (2015). In vitro activity of tigecycline in combination with cefoperazone-sulbactam against multidrug-resistant Acinetobacter baumannii. Journal of Chemotherapy, 27(5), 271–276.

Zhengfeng Jia | Medicine | Excellence in Research

Published on by Forensic Scientist

Prof. Dr. Zhengfeng Jia | Medicine | Excellence in Research

Fourth medical PLA general hospital | China

Dr. Zhengfeng Jia is a researcher in orthopedic biomechanics, focusing on distal humerus fractures, musculoskeletal dynamics, and finite element analysis. Affiliated with the Chinese PLA General Hospital and the National Clinical Research Center for Orthopedics, his work bridges computational modeling and clinical applications to optimize fracture fixation and rehabilitation strategies.

Professional profile👤

Scopus

Strengths for the Awards✨

  1. Innovative Methodology

    • The study integrates musculoskeletal dynamics (AnyBody software) with finite element analysis (Abaqus) to simulate real-world biomechanical conditions, overcoming the limitations of traditional static models.

    • The AnyBody-Abaqus coupling technique provides dynamic loading conditions, capturing muscle forces and joint reactions during elbow flexion/extension, which is rare in orthopedic biomechanics research.

  2. Clinical Relevance

    • Addresses a critical gap in distal humerus fracture management by quantifying “safe activity windows” for postoperative rehabilitation (e.g., ≤80° flexion for parallel plates, ≤30° for vertical plates).

    • Findings directly inform surgical decisions (e.g., plate configuration) and rehabilitation protocols to reduce complications like non-union.

  3. Rigorous Validation

    • Validates muscle forces using electromyography (EMG) literature and mesh convergence studies to ensure computational accuracy (<5% error).

    • Anatomical accuracy is confirmed via statistical shape modeling (SSM) and iterative closest point (ICP) algorithms (<1.2 mm error).

  4. High-Impact Results

    • Demonstrates that parallel plates outperform vertical plates in maintaining interfragmentary motion (IFM) within the healing threshold (0.06–0.20 mm).

    • Identifies stress migration paths in the humerus, correlating with anatomical weak zones (e.g., lateral condyle).

  5. Interdisciplinary Approach

    • Combines orthopedic surgery, biomechanics, and computational modeling, aligning with the trend of “smart orthopedics.”

Education 🎓

  • PhD Candidate in Orthopedics, Graduate School of Medical School of Chinese PLA Hospital, Beijing (Current).

  • Research training in musculoskeletal dynamics, 3D modeling, and finite element analysis (FEA).

Experience 💼

  • Researcher at the Fourth Medical Center of Chinese PLA General Hospital, Beijing.

  • Specializes in digital orthopedic technologies, including AnyBody-Abaqus joint modeling and biomechanical simulations.

  • Collaborates on studies quantifying “safe activity windows” for postoperative rehabilitation.

Research Interests On Medicine 🔍

  • Biomechanics of distal humerus fractures.

  • Musculoskeletal dynamics and finite element analysis (FEA).

  • Optimization of internal fixation plates and rehabilitation protocols.

  • AI applications in orthopedic decision-making.

Awards & Nominations 🏆

  • National Clinical Research Center for Orthopedics Grant (2024) for data-driven ulnar prostheses research.

  • Ethical approval recipient (2024KY005-KS001) for studies on fracture healing biomechanics.

Publications 📚

  1. Jia, Z., Xu, C., Gao, W., et al. (2025). Evaluation of internal fixation stability of distal humerus C-type fractures based on musculoskeletal dynamics: Finite element analysis under dynamic loading. Journal of Orthopaedic Surgery and Research, *20*(475).

  2. Contributed to meta-analyses on continuous passive motion post-arthroplasty (J Orthop Surg Res, 2024).

Conclusion 🌟

Zhengfeng Jia’s multidisciplinary research quantifies biomechanical thresholds for fracture healing, emphasizing parallel plate configurations and 30–80° flexion safety windows. His integration of AnyBody-Abaqus modeling advances personalized rehabilitation strategies, with future aims to validate findings in clinical trials and AI-driven orthopedic solutions.