Prof. Dr. Zhi Guo | Medicine and Health Sciences | Editorial Board Member
Huazhong University of Science and Technology Union Shenzhen Hospital | China
Dr. Zhi Guo is a distinguished hematology researcher whose work focuses on hematological malignancies, hematopoietic stem cell transplantation, and tumor-related microecology. According to Scopus (Author ID: 24279665000), he has 77 indexed publications, 713 citations from 663 documents, and an h-index of 10, reflecting a solid and growing scholarly influence. His research has significantly advanced precision immunotherapy, particularly through clinical and translational innovations in CAR-T cell engineering, including anti-CD19, anti-CD7, and anti-BCMA CAR-T therapies, while contributing real-world evidence to lymphoma treatment and transplantation practices. He has also played a central role in developing expert consensus guidelines in tumor microecology, intestinal microbiota, and hematology-related infectious disease management. His research portfolio spans oral–intestinal microbiome interactions, graft-versus-host disease, microecological regulators, novel cryoprotectants, and stem-cell-based immunotherapies. With over ten completed or ongoing research projects, multiple consultancy-linked studies, and several books published with ISBN registration, he demonstrates strong multidisciplinary contributions to hematology and R&D innovation. His work in systematic reviews, meta-analyses, and multicenter clinical studies highlights his commitment to evidence-based medicine. Dr. Guo’s extensive experience in hematopoietic stem cell transplantation—supported by more than 1,300 clinical cases—continues to fuel impactful research outputs and leadership in national expert consensus development across oncology, immunology, and microecology research domains.
Profile: Scopus
Featured Publications
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Guo, Z., et al. (2025). In vitro functional validation of anti-CD19 chimeric antigen receptor T cells expressing lysine-specific demethylase 1 short hairpin RNA for the treatment of diffuse large B cell lymphoma. Frontiers in Immunology, 15, 1521778. https://doi.org/10.3389/fimmu.2025.1521778
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Guo, Z., et al. (2025). The case of T-cell acute lymphoblastic leukemia treated with chemotherapy followed by anti-CD7 CAR-T cells using retroviral vector. Frontiers in Immunology, 15, 1519055. https://doi.org/10.3389/fimmu.2025.1519055
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Guo, Z., et al. (2025). Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life. Frontiers in Pediatrics, 13, 1471743. https://doi.org/10.3389/fped.2025.1471743
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Guo, Z., et al. (2024). The role of fecal microbiota transplantation in the treatment of acute graft-versus-host disease. Journal of Cancer Research and Therapeutics, 20(7), 1964–1973. https://doi.org/10.4103/jcrt.jcrt_1372_22
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Guo, Z., et al. (2024). Rapid response in relapsed follicular lymphoma to novel anti-CD19 CAR-T therapy with pseudo-progression and cytomegalovirus infection: A case report. International Immunopharmacology, 134, 112174. https://doi.org/10.1016/j.intimp.2024.112174
