MD, PhD | University of Bucharest | Romania
Amuzescu P. Bogdan is an esteemed Romanian scientist specializing in neurobiology, electrophysiology, and mathematical modeling of biological systems. Born on November 27, 1965, in Bucharest, Romania, he has made significant contributions to the fields of membrane biophysics, cardiomyocyte modeling, and cellular physiology. A dedicated academic and researcher, he currently serves as an Associate Professor at the University of Bucharest.
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Strengths for the Awards
- Extensive Research Background:
Dr. Amuzescuās academic and research trajectory spans decades, covering interdisciplinary domains such as biophysics, neurobiology, electrophysiology, and mathematical modeling of biological systems. With numerous positions held in academia and research, he demonstrates profound expertise in fundamental and applied sciences.
- Significant Contributions to Science:
- Published 39 original scientific papers, including 23 in ISI-quoted journals, showcasing impactful contributions to areas such as ion channel electrophysiology, cardiomyocyte biophysics, and neural signaling.
- Notable achievements include the development of electrophysiological models, discovery of novel effects of amitriptyline on ASIC1a ion channels, and pioneering studies on TRPV1 currents and Mg2+-regulated ion channels.
- Research Grants and Funding:
Dr. Amuzescu has successfully contributed to and led several prestigious research grants, including those funded by the World Bank, NATO, and Volkswagen Foundation, as well as significant EU structural grants. His role as grant coordinator and scientific manager highlights his ability to manage and execute large-scale projects effectively.
Education š
Amuzescu P. Bogdan’s academic journey began in Bucharest, where he attended Elementary School No. 80 and Secondary School No. 117. He graduated from the renowned St. Sava National College in 1984, focusing on mathematics and physics. After earning his medical degree from the Carol Davila University of Medicine and Pharmacy in 1991, he pursued a Masterās in Neurobiology at the University of Bucharest (1999-2000) and completed his PhD (2000-2003) on the properties of ion channels in biomembranes, mentored by Prof. Maria-Luisa Flonta and international collaborators.
Professional Experience š¼
Amuzescu has amassed extensive teaching and research experience over the years. His career highlights include:
- 1991-1992: Assistant roles in Biophysics and Nuclear Medicine in ConstanČa.
- 1992-2000: Clinical practice as a specialist physician in hematology and internal medicine.
- 2000-Present: Academic roles at the University of Bucharest, where he advanced from Assistant Lecturer to Associate Professor.
- 2014-2015: Application Scientist at Cytocentrics Bioscience GmbH, Germany.
His teaching repertoire includes neurobiophysics, anatomy, physiology, and clinical diagnostics.
Research Interests On Toxicology š¬
Amuzescu’s expertise spans:
- Mathematical modeling of complex biological systems, particularly in cardiology and neurology.
- Electrophysiology, focusing on ion channels, nociception, and pain mechanisms.
- Cardiac safety pharmacology and drug safety profiling.
- Developing innovative methodologies, such as automated patch-clamp technologies.
His work explores diseases like diabetic neuropathy, Alzheimer’s, and ischemic conditions, integrating molecular and systemic perspectives.
Awards and Recognition š
- 2005: First Prize for Scientific Communication, Romanian Neuroscience Society.
- Invited reviewer for prestigious journals, including the European Journal of Pharmacology and Journal of Neuroscience Methods.
- Leader of the Group of Mathematical Modeling of Complex Biological Systems at the University of Bucharest.
Publications š
- Magnesiumāinhibited, TRPM6/7ālike channel in cardiac myocytes: permeation of divalent cations and pHāmediated regulation
- Authors: A Gwanyanya, B Amuzescu, SI Zakharov, R Macianskiene, KR Sipido, …
- Year: 2004
- Citations: 113
- Action potential characterization of human induced pluripotent stem cellāderived cardiomyocytes using automated patch-clamp technology
- Authors: O Scheel, S Frech, B Amuzescu, J Eisfeld, KH Lin, T Knott
- Year: 2014
- Citations: 97
- Cooling inhibits capsaicin-induced currents in cultured rat dorsal root ganglion neurones
- Authors: A Babes, B Amuzescu, U Krause, A Scholz, ML Flonta, G Reid
- Year: 2002
- Citations: 50
- A system for applying rapid warming or cooling stimuli to cells during patch clamp recording or ion imaging
- Authors: G Reid, B Amuzescu, E Zech, ML Flonta
- Year: 2001
- Citations: 50
- Evolution of mathematical models of cardiomyocyte electrophysiology
- Authors: B Amuzescu, R Airini, FB Epureanu, SA Mann, T Knott, BM Radu
- Year: 2021
- Citations: 39
- Catecholamines reduce transient receptor potential vanilloid type 1 desensitization in cultured dorsal root ganglia neurons
- Authors: A Filippi, C Caruntu, RO Gheorghe, A Deftu, B Amuzescu, V Ristoiu
- Year: 2016
- Citations: 25
- Zinc is a voltage-dependent blocker of native and heterologously expressed epithelial Na+ channels
- Authors: B Amuzescu, A Segal, ML Flonta, J Simaels, W Van Driessche
- Year: 2003
- Citations: 25
- Extracellular trypsin increases ASIC1a selectivity for monovalent versus divalent cations
- Authors: E Neaga, B Amuzescu, C Dinu, B Macri, F Pena, ML Flonta
- Year: 2005
- Citations: 24
- Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp
- Authors: SA Mann, J Heide, T Knott, R Airini, FB Epureanu, AF Deftu, AT Deftu, …
- Year: 2019
- Citations: 23
- Aspartame safety as a food sweetener and related health hazards
- Authors: SAA Shaher, DF Mihailescu, B Amuzescu
- Year: 2023
- Citations: 22
Conclusion š¤
Amuzescu P. Bogdan’s career reflects a unique blend of medical expertise, academic rigor, and groundbreaking research in neurobiology and physiology. Through his dedication to teaching, innovative research, and interdisciplinary collaborations, he continues to contribute profoundly to understanding complex biological systems and developing therapeutic strategies.
