Prof. Dr. Huai-Jen Tsai | Biochemistry, Genetics and Molecular Biology | Research Excellence Award

Institute of Life Science, Fu-Jen Catholic University | Taiwan

Prof. Dr. Huai-Jen Tsai is a distinguished molecular biologist whose research spans developmental biology, marine biotechnology, and gene transgenesis in aquatic organisms, with a particular focus on zebrafish and other finfish models. He has pioneered innovative sperm-mediated and electroporation-based gene transfer systems, enabling highly efficient transgenesis in finfish and shellfish, and has significantly advanced understanding of growth hormone regulation, gonadotropins, rhodopsins, and muscle-specific transcription factors, thereby contributing to both vertebrate developmental biology and aquaculture applications. Prof. Dr. Huai-Jen Tsai’s work bridges fundamental molecular biology and applied biotechnology, investigating molecular mechanisms regulating embryonic development, stress responses, and neural regeneration, including studies on ENDOU-mediated translation regulation and the role of extracellular proteins in promoting neurite outgrowth and spinal cord repair. He has authored 162 documents indexed in Scopus, which have been cited over 5,174 times by 4,191 publications, and he holds an h-index of 36, reflecting the high impact and wide recognition of his contributions in the scientific community. Throughout his career, Prof. Dr. Huai-Jen Tsai has received numerous prestigious awards, including the MOST Outstanding Research Award, Y. Z. Hsu Technology Invention Award for a patented zebrafish gene fragment, and multiple NSC Outstanding Research Awards, and he has served as principal investigator on numerous funded research projects. In addition, he contributes extensively as a reviewer and editorial board member for international journals. His research continues to integrate molecular genetics, developmental studies, and biotechnological innovation, establishing him as a leading authority in aquatic molecular genetics, transgenic technologies, and regenerative biology, and underscoring his influential role in advancing both basic science and translational applications in vertebrate and aquatic systems.

Profiles: Scopus | ORCID

Featured Publications

• Lee, H.-C., Huang, Y.-H., Hsieh, C.-C., Ke, Y.-N., & Tsai, H.-J. (2025). ENDOU-1-induced cytoplasmic HnRNPA3 recognizes m6A methylation on the upstream reading frame of human CHOP transcripts to achieve maximal CHOP translation. Preprint.

• Lee, B.-C., Tsai, J.-C., Huang, Y.-H., Wang, C.-C., Lee, H.-C., & Tsai, H.-J. (2024). The 419th aspartic acid of neural membrane protein enolase 2 is a key residue involved in axonal growth of motor neurons mediated by interaction between enolase 2 receptor and extracellular Pgk1 ligand. International Journal of Molecular Sciences, 25(19), 10753.

• Lee, H.-C., Chao, H.-T., Lee, S. Y.-H., Lin, C.-Y., & Tsai, H.-J. (2023). The upstream 1350~1250 nucleotide sequences of the human ENDOU-1 gene contain critical cis-elements responsible for upregulating its transcription during ER stress. International Journal of Molecular Sciences, 24(24), 17393.

• Zeng, C.-W., & Tsai, H.-J. (2023). The promising role of a zebrafish model employed in neural regeneration following a spinal cord injury. International Journal of Molecular Sciences, 24(18), 13938.

• Fu, C.-Y., Chen, H.-Y., Lin, C.-Y., Chen, S.-J., Sheu, J.-C., & Tsai, H.-J. (2023). Extracellular Pgk1 interacts with neural membrane protein enolase-2 to improve neurite outgrowth of motor neurons. Communications Biology, 6, 822.