Huai-Jen Tsai | Biochemistry, Genetics and Molecular Biology | Research Excellence Award

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Prof. Dr. Huai-Jen Tsai | Biochemistry, Genetics and Molecular Biology | Research Excellence Award

Institute of Life Science, Fu-Jen Catholic University | Taiwan

Prof. Dr. Huai-Jen Tsai is a distinguished molecular biologist whose research spans developmental biology, marine biotechnology, and gene transgenesis in aquatic organisms, with a particular focus on zebrafish and other finfish models. He has pioneered innovative sperm-mediated and electroporation-based gene transfer systems, enabling highly efficient transgenesis in finfish and shellfish, and has significantly advanced understanding of growth hormone regulation, gonadotropins, rhodopsins, and muscle-specific transcription factors, thereby contributing to both vertebrate developmental biology and aquaculture applications. Prof. Dr. Huai-Jen Tsai’s work bridges fundamental molecular biology and applied biotechnology, investigating molecular mechanisms regulating embryonic development, stress responses, and neural regeneration, including studies on ENDOU-mediated translation regulation and the role of extracellular proteins in promoting neurite outgrowth and spinal cord repair. He has authored 162 documents indexed in Scopus, which have been cited over 5,174 times by 4,191 publications, and he holds an h-index of 36, reflecting the high impact and wide recognition of his contributions in the scientific community. Throughout his career, Prof. Dr. Huai-Jen Tsai has received numerous prestigious awards, including the MOST Outstanding Research Award, Y. Z. Hsu Technology Invention Award for a patented zebrafish gene fragment, and multiple NSC Outstanding Research Awards, and he has served as principal investigator on numerous funded research projects. In addition, he contributes extensively as a reviewer and editorial board member for international journals. His research continues to integrate molecular genetics, developmental studies, and biotechnological innovation, establishing him as a leading authority in aquatic molecular genetics, transgenic technologies, and regenerative biology, and underscoring his influential role in advancing both basic science and translational applications in vertebrate and aquatic systems.

Profiles: Scopus | ORCID

Featured Publications

  • Lee, H.-C., Huang, Y.-H., Hsieh, C.-C., Ke, Y.-N., & Tsai, H.-J. (2025). ENDOU-1-induced cytoplasmic HnRNPA3 recognizes m6A methylation on the upstream reading frame of human CHOP transcripts to achieve maximal CHOP translation. Preprint.

  • Lee, B.-C., Tsai, J.-C., Huang, Y.-H., Wang, C.-C., Lee, H.-C., & Tsai, H.-J. (2024). The 419th aspartic acid of neural membrane protein enolase 2 is a key residue involved in axonal growth of motor neurons mediated by interaction between enolase 2 receptor and extracellular Pgk1 ligand. International Journal of Molecular Sciences, 25(19), 10753.

  • Lee, H.-C., Chao, H.-T., Lee, S. Y.-H., Lin, C.-Y., & Tsai, H.-J. (2023). The upstream 1350~1250 nucleotide sequences of the human ENDOU-1 gene contain critical cis-elements responsible for upregulating its transcription during ER stress. International Journal of Molecular Sciences, 24(24), 17393.

  • Zeng, C.-W., & Tsai, H.-J. (2023). The promising role of a zebrafish model employed in neural regeneration following a spinal cord injury. International Journal of Molecular Sciences, 24(18), 13938.

  • Fu, C.-Y., Chen, H.-Y., Lin, C.-Y., Chen, S.-J., Sheu, J.-C., & Tsai, H.-J. (2023). Extracellular Pgk1 interacts with neural membrane protein enolase-2 to improve neurite outgrowth of motor neurons. Communications Biology, 6, 822.

Roya Mirzaei | Molecular Biology | Best Researcher Award

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Dr. Roya Mirzaei | Molecular Biology | Best Researcher Award

Shahid Beheshti University of Medical of sciences | Iran

Dr. Roya Mirzaei is a distinguished Iranian toxicologist and biomedical researcher, currently serving as a Postdoctoral Research Fellow at the Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences (2023–2025). Her academic journey encompasses a Ph.D. in Toxicology (2017–2022) and an MSc in Toxicology (2013–2015) from the Islamic Azad University of Tehran Medical Sciences, following a Bachelor’s degree in Medical Laboratory Sciences from Hamedan University of Medical Sciences (2013). Dr. Mirzaei’s research is deeply rooted in cancer biology, immunotherapy, and molecular toxicology, with a particular focus on the development of recombinant antibodies and the exploration of natural toxins for therapeutic applications. Her prolific contributions to scientific literature and active participation in peer review processes underscore her commitment to advancing medical science.

Professional profile👤

Google Scholar

ORCID

Scopus

Strengths for the Awards✨

Dr. Roya Mirzaei demonstrates exceptional strength in interdisciplinary cancer research, toxicology, and immunopharmacology. With a Ph.D. in Toxicology and ongoing postdoctoral fellowship at the Shahid Beheshti University of Medical Sciences, her research trajectory reflects depth, innovation, and collaboration. Her scientific contributions include 16 peer-reviewed publications, many of which explore novel anti-cancer therapeutics using recombinant antibodies, mitochondrial targeting, and venom-derived compounds. Notably, her publication in high-impact journals like International Immunopharmacology (IF: 5.71) and Environmental Science and Pollution Research (IF: 5.8) marks her as a front-runner in translational research.

🎓 Education

  • Postdoctoral Research Fellow
    Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences (2023–2025)

  • Ph.D. in Toxicology
    Faculty of Pharmacy, Islamic Azad University of Tehran Medical Sciences (2017–2022)

  • MSc in Toxicology
    Faculty of Pharmacy, Islamic Azad University of Tehran Medical Sciences (2013–2015)

  • Bachelor’s Degree in Medical Laboratory Sciences
    Hamedan University of Medical Sciences (2013)

💼 Professional Experience

  • Scientific Researcher
    Recombinant Proteins Department, Motamed Cancer Institute (2021–2023)
    Dr. Mirzaei played a pivotal role in designing and implementing studies, collecting data, and analyzing results, particularly focusing on cancer stem cells and bi-specific antibodies.

  • Research Assistant
    Biotechnology Department, Pasteur Institute of Iran (2014–2018)
    She collaborated with students, provided research guidance, and executed various experimental techniques, contributing to projects involving venom-derived compounds and gene expression studies.

🔬 Research Interests On Molecular Biology

Dr. Mirzaei’s research interests are centered on the cellular and molecular mechanisms involved in cancer and its immunotherapy. She is particularly intrigued by the rapidly evolving fields of tumor immunology and cancer biology, employing both in vitro and in vivo models, as well as bioinformatics tools, to unravel complex biological processes. Her work often intersects with areas such as cellular immunology, cell biology, and the development of novel therapeutic strategies.

🏆 Awards & Honors

  • Top Researcher
    Student Section, Islamic Azad University of Medical Sciences, Tehran-Iran (2018 & 2023)

  • Editorial Board Member
    26th Edition of International Conference on Oncology and Cancer Research, Pencis (2025)

  • Memberships

    • Society of Toxicology (SOT), USA – Postdoctoral Member (2021–Present)

    • Iranian Society of Toxicology (IranTox) (2018–Present)

    • Iranian Society of Physiology and Pharmacology (PHYPHA) (2022–Present)

  • Educational Contributions

    • Co-authored the “IQB: Decennial Iran Question Bank” for Ph.D. Toxicology exams (2018)

    • Translated the latest edition of “Cecil Textbook of Medicine: Cardiovascular Diseases” into Persian (2021)

    • Conducted an online course on Clinical Toxicology via Faradars (2022)

📚 Publications

Dr. Mirzaei has an extensive list of publications in reputable journals. Below are selected works with hyperlinks, publication years, journals, and citation information:

  1. The Recombinant Anti-MET/EpCAM Bispecific Antibody Fragment: A Promising Novel Therapeutic Approach for Breast Cancer Treatment
    Investigational New Drugs, 2025.
    Link
    Cited by: 3 articles

  2. Exploring the Potential of Mitochondria-Targeted Drug Delivery for Enhanced Breast Cancer Therapy
    International Journal of Breast Cancer, 2025.
    Link
    Cited by: 2 articles

  3. Strain-Specific Effects of Probiotics on Depression and Anxiety: A Meta-Analysis
    Gut Pathogens, 2024.
    Link
    Cited by: 5 articles

  4. Production of Novel Recombinant Anti-EpCAM Antibody as Targeted Therapy for Breast Cancer
    International Immunopharmacology, 2023.
    Link
    Cited by: 6 articles

  5. Increased Risk of Primary Ovarian Insufficiency by High-Fructose Diet: A 90-Day Hormonal and Immunohistochemical Study in Wistar Rats
    Environmental Science and Pollution Research, 2022.
    Link
    Cited by: 3 articles

  6. The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis
    Iranian Biomedical Journal, 2023.
    Link
    Cited by: 2 articles

  7. Repurposing the Drug, Ivermectin, in COVID-19: Toxicological Points of View
    European Journal of Medical Research, 2022.
    Link
    Cited by: 4 articles

  8. Development of a MET-Targeted Single-Chain Antibody Fragment as an Anti-Oncogene Targeted Therapy for Breast Cancer
    Investigational New Drugs, 2023.
    Link
    Cited by: 5 articles

  9. Synthesized Anti-HER2 Trastuzumab-MCC-DM1 Conjugate: An Evaluation of Efficacy and Cytotoxicity
    Iranian Journal of Immunology, 2023.
    Link
    Cited by: 2 articles

  10. Increased Risk of Cerebral Dysfunction by High-Fructose Diet Consumption: A 90-Day Study in Female Rats
    Health Biotechnology and Biopharma, 2023.
    Link
    Cited by: 1 article

🧾 Conclusion

Dr. Roya Mirzaei exemplifies the qualities of a dedicated and innovative researcher in the fields of toxicology and cancer biology. Her extensive academic background, coupled with her hands-on experience in leading research institutions, has led to significant contributions to scientific knowledge, particularly in the development of targeted therapies and the understanding of dietary impacts on health. Her commitment to education, as evidenced by her teaching and translation work, further highlights her dedication to the dissemination of scientific knowledge. Dr. Mirzaei’s achievements make her a deserving candidate for recognition and accolades in her field.